Their molecular weight is around 150,000 (7S).For this reason, it takes time for B-cells to generate IgG. Thus, at the time of their production, B-cells have to undergo class switching. And thus, it is a part of the secondary or delayed immune response. Our body produces them in the later stages of the infection. It constitutes around 80% of the total antibody concentration in blood serum. IgG is the most commonly found immunoglobulin in our body. Low level of IgM results in few types of leukaemia, and some inherited diseases. Low level of IgG results in kidney damage and few types of infections. High level of IgM may give rise to parasitic infections, kidney damage, rheumatoid arthritis, hepatitis, mononucleosis. High level of IgG in the body means a long-term infection like HIV, multiple sclerosis, multiple myeloma. IgM is found in lymph fluid and blood and is produced in plasma cells. IgM serves as the first kind of defense, which means it is the first antibody to be immediately developed when any foreign particle is introduced, though its function is temporary.Ībundantly found in lymph, blood, and intestine. ![]() ![]() IgG is a long term response for any disease and thus protect our body from viral and bacterial attacks. It is pentamer consisting of 5 Y-shaped units together by a polypeptide chain with ten antigen binding sites. It is a monomer consisting of the single Y-shaped unit with only two antigen binding sites. Content: Immunoglobulin M (IgM) Vs Immunoglobulin G (IgG) In this context, we will study the differences between the structure and functions of IgM and IgG. They survive in the bloodstream for a longer duration of time, unlike IgM. It acts as an effective fighter that defends the body during the secondary immune response. It is the most abundantly found antibody in the blood. The body generates them in later stages of infection after asserting the antigenic properties. On the other hand, the IgG are generated as a delayed response. Thus, their presence in the blood confirms the existence of infection in the body.īut they are very short-lived and temporary and get dissolved after some weeks of exposure. It is the first type of immunoglobulin generated after disease exposure. As soon as any foreign antigen encounters the body, the production of IgM immediately starts.
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